Contraindications to the use of drugs: hypersensitivity to the drug, active liver disease or persistent increase activity of the serum transaminases, pregnancy and lactation, children under 9. Indications for use drugs: used in patients with high risk of CHD (with or without the presence of hyperlipidemia it), for example sexology with diabetes, patients with stroke or other cerebrovascular diseases in anamnesis, patients with peripheral vascular disease, Abdominal X-Ray patients with CHD, as an adjunct to diet to reduce elevated level of total cholesterol, LDL cholesterol, triglycerides, apolipoprotein B in adolescents aged Bronchoalveolar Lavage Carcinoma 17 years with heterozygous familial hyperlipidemia, to increase HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia or mixed hypercholesterolemia, use only when diet and other non- treatment is not enough, for the treatment of patients sexology hypertriglyceridemia, primary dysbetalipoproteyinemiya, in addition to diet and other ways to treat patients with homozygous familial hypercholesterolemia. / day during one of the main meals, diet, started to use the drug, should continue, and if after the drug within 3 months) the level of lipids in the blood serum not declined to consider the appointment of additional treatment or other therapy sexology . Method of production of drugs: Table., Coated tablets 5 mg, 10 mg, 20 mg, 40 mg, 80 mg. The main pharmaco-therapeutic action: the hypolipidemic effect; holesterynznyzhuyuchyy synthetic agent, is a competitive inhibitor of HMG CoA reductase, does the main action in the liver and is mainly ratsematom erytroenantiomeriv two, one of which has pharmacological activity, inhibition of cholesterol biosynthesis reduces its content in liver cells, sexology stimulates the synthesis Persistent Vegetative State receptors and thus enhances the capture of particles of LDL, the end result of such mechanisms is to reduce the concentration cholesterol in plasma, reduces total cholesterol (total Chemiluminescence), low density lipoprotein cholesterol (LDL), apolipoprotein B (APO B), and triglycerides (TG) and slightly increases high density lipoprotein cholesterol (HDL) in patients with hypercholesterolemia and mixed dyslipidemia; Slow Release for 2 weeks therapeutic response, and maximum response is achieved within 4 weeks after initiation of treatment and stabilized during prolonged therapy. Pharmacotherapeutic group: S10AV05 - hypolipidemic agents. Side effects and complications in the use of drugs: abdominal pain, constipation, bloating, asthenia, headache, myopathy; nausea, diarrhea, skin rash, indigestion, itching, alopecia, dizziness, cramps, myalgia, pancreatitis, paresthesia, peripheral neuropathy, vomiting and anemia, rhabdomyolysis and hepatitis / jaundice; expressed c-m hypersensitivity, which occurs angioedema, vovchakopodibnym c-IOM, polymyalgia rheumatica, vasculitis, thrombocytopenia, eosinophilia, ESR increase, arthritis, here urticaria, changes in laboratory parameters - sometimes significant and sustained increase levels serum transaminases, sexology phosphatase and gamma-hlyutamil transpeptydazy, increased serum levels of Creatine musculoskeletal origin. Dosing and Administration of drugs: in combination with diet therapy sexology designed for long-term symptomatic treatment; appoint 1 kaps. Pharmacotherapeutic group: S10AA04 - hypolipidemic zasoby.Inhibitory HMG-CoA reductase.
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